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Welcome to the blog of Rochester's Science Cafe! Science Cafes are interactive events involving face-to-face conversations with leading scientists about relevant current topics. Ours meets on the fourth Tuesday of the month in the Community Room on the second Floor of the Pittsford Plaza Barnes and Noble.
Hello to all the devoted friends and attendees of the Rochester Science Cafe!
Starting this Fall, and continuing on until it is deemed safe for us all to meet in person again, the Rochester Science Cafe is moving to Zoom (the Rochester Zience Cafe?). See below for details on how to join, and how to ask questions.
Our Fall 2020 series will begin on September 22, and continue on monthly. The first talk will be:
September 22, 7pm: https://rit.zoom.us/j/96028743897
The Road to a Pandemic COVID-19 Vaccine
Dr. Angela Branche
Assistant Professor, Department of Medicine, Infectious Diseases
University of Rochester Medical Center
To join the Cafe, simply follow the Zoom link above. Please note that Cafes will be recorded, so we can reach the broadest audience possible. There will be two ways to ask a question:
We will allow the audience to leave their video on, but we recommend turning it off while you are just listening to save bandwidth, turning it on to ask a question.
During her years at the University of Rochester her focus in research involved the use of viral molecular and immunological diagnostic assays to explore the pathogenesis and host response to acute viral respiratory illnesses in adults. She is currently the clinical director of the NIH Center for Excellence in Influenza Research and Surveillance (CEIRS) New York Influenza Center of Excellence (NYICE) and Co-Principal Investigator for the UR Vaccine Treatment and Evaluation Unit (UR VTEU). Her current research activities explore clinical disease, pathogenesis, development of therapeutics and vaccine biology related to infection with viral and bacterial respiratory pathogens. Studies include assessment of asymptomatic carriage of Streptococcus pneumoniae and the impact of pneumococcal vaccination, surveillance of epidemic influenza infections and immunologic mechanisms of protection following natural infection versus vaccination, the development of pandemic influenza vaccines, population-based studies of RSV infection and the development of vaccine and anti-viral agents for RSV. Current efforts also include the study of the pathogenesis and immune response to pandemic SARS Coronavirus 2 infections and clinical interventional trials for the development of COVID19 therapeutic agents and vaccines. She is a member of the Infectious Disease Society of America and the NIH Human Cohorts Steering Committee and NIH IDCRC Emerging Infectious Expert Working Group. Dr. Branche has published several peer-reviewed articles, reviews and book chapters related to respiratory viral pathogens in adults.
We will discuss the rapidly evolving field of artificial intelligence to help us understand what exactly AI is, and whether we should be concerned or elated.
I had a couple of folks ask me for links to further reading etc. So, if you have a mailing list, here are some suggestions:
https://www.ted.com/talks/anil_seth_your_brain_ hallucinates_your_conscious_ reality
https://www.ted.com/talks/donald_hoffman_do_we_see_ reality_as_it_is?language=en
https://www.newyorker.com/magazine/2018/04/02/the-mind- expanding-ideas-of-andy-clark
And for the more committed folks:
https://www.fil.ion.ucl.ac.uk/~karl/Whatever%20next.pdf
https://www.amazon.com/Surfing-Uncertainty- Prediction-Action-Embodied/dp/ 0190217014
https://www.amazon.com/Case-Against-Reality-Evolution- Truth/dp/0393254690
https://www.amazon.com/Predictive-Mind-Jakob-Hohwy/ dp/0199686734
Circadian rhythms in mammals are 24-hour cycles that govern gene regulation and cellular metabolism. While many cancers have altered or disrupted circadian rhythms, there is little understanding of the implications of this disruption on cancer cell metabolism, tumor cell growth, and prognosis. We have previously shown that the MYC oncogene, commonly overexpressed in many human cancers, disrupts circadian rhythm and metabolic oscillations, which may provide a growth advantage to the cancer cell.https://www.urmc.rochester.edu/labs/altman.aspx
Our research focuses on identifying the intersections between circadian rhythm, cancer cell physiology, and metabolism. We utilize diverse cell line models of cancer and mouse MYC-driven lung cancer to focus on amplified MYC, the extended MYC family of related proteins, and nutrient input and metabolic stress signaling in circadian rhythm control. Better understanding of how tumors and metabolic input modulate the clock and the circadian metabolic cycle could aid in developing novel treatment strategies to time increased efficacy and reduced toxicity.
The Michel research group has focused on the Peptidoglycan associated lipoprotein (Pal) protein from two pathogenic bacteria: nontypeable Haemophilus influenza (NTHi) and Escherichia coli (E. coli). NTHi causes ear infections and other respiratory illnesses, including chronic obstructive pulmonary disease (COPD). The Michel group aims to use the NTHi Pal protein in a vaccine to protect against these diseases. E. coli can be found in the human gut, where they act as a “good bacteria,” helping to maintain gut health. However, E. coli can also cause serious illnesses, including sepsis, which is extreme inflammation caused by a serious infection. In this research realm, the Michel group studies the role of Pal in sepsis and aims to prove that Pal is a useful biomarker for early detection and diagnosis of E. coli sepsis.https://www.rit.edu/science/michel
This conversation will unapologetically make a series of bold claims seeking to make the case that the Bayesian Paradigm just might be the single most fundamental building block of statistical machine learning and data science. A tour of some foundational concepts in statistics and machine learning will serve as the fulcrum for anchoring all the claims, but concrete examples of the power of the Bayesian thought in modern data science will also be provided.
Antibiotic resistance is one of the major public health challenges of the 21st century. The recent death of a United States citizen who became ill with an infection caused by Klebsiella pneumoniaethat was resistant to twenty-six antibiotics highlights this important issue. The rise in the number of multidrug-resistant bacteria such as; Methicillin-resistant Staphylococcus aureus, Vancomycin inter-mediate and resistant Staphylococcus aureus, Pseudomonas aeruginosa (multidrug resistant strains), multi-drug resistant Mycobacterium tuberculosis among others has led to a significant increase in the morbidity and mortality of humans infected with pathogenic bacteria.
Thousands of extrasolar planets ("exoplanets") have been discovered over the past two decades. Astronomers seeking to understand the astonishing variety of planetary masses and orbital separations that characterize these myriad exoplanet systems, as well as the earliest evolution of our own solar system, must carefully study exoplanet birthplaces: dusty, molecule-rich “protoplanetary” disks orbiting young stars. Here, I'll talk about recent advances in the study of protoplanetary disks using the recently commissioned Atacama Large Millimeter Array (ALMA) radio interferometer as well as the latest generation of adaptive optics (AO) cameras on the world’s largest (8-meter-class) optical/infrared telescopes. My talk will focus on ALMA and AO studies of the nearest-known disks; these young neighbors afford opportunities to image disk structures and chemistry on solar system size scales. Also, I'll talk about finding the source of the air we breathe, from an astronomical perspective.